| Date | Location | Result | |
| 11/13/21 | Gaffney, S.C. | Newberry 42, Limestone 7 | Box score |
| 11/6/21 | Jefferson City, Tenn | Carson-Newman 27, Limestone 21 | Box score |
| 10/30/21 | Gaffney, S.C. | UVA Wise 28, Limestone 24 | Box score |
| 10/23/21 | Hickory, N.C. | Lenoir-Rhyne 45, Limestone 3 | Box score |
| 10/16/21 | Gaffney, S.C | Mars Hill 32, Limestone 3 | Box score |
| 10/9/21 | Gaffney, S.C. | Wingate 35, Limestone 17 | Box score |
| 9/25/21 | Gaffney, S.C. | Barton 45, Limestone 7 | Box score |
| 9/18/21 | Greeneville, Tenn. | Tusculum 24, Limestone 21 | Box score |
| 9/4/21 | Tigerville, S.C. | North Greenville 37, Limestone 16 | Box score |