| Date | Location | Result | |
| 02/26/22 | Gaffney, SC | Lincoln Memorial 85, Limestone 72 | Box score |
| 02/23/22 | Gaffney, SC | Limestone 72, Mars Hill 59 | Box score |
| 02/21/22 | Gaffney, S.C. | Tusculum 74, Limestone 58 | Box score |
| 02/19/22 | Jefferson City, Tenn. (Holt Fieldhouse) | Carson-Newman 89, Limestone 70 | Box score |
| 02/16/22 | Charlotte, NC | Queens (NC) 73, Limestone 66 | Box score |
| 02/09/22 | Gaffney, SC | Wingate 75, Limestone 58 | Box score |
| 02/05/22 | Hickory, NC | Lenoir-Rhyne 73, Limestone 65 | Box score |
| 02/02/22 | Gaffney, SC | Limestone 83, Coker 56 | Box score |
| 01/31/22 | Mars Hill, NC | Limestone 87, Mars Hill 72 | Box score |
| 01/29/22 | Wise, VA | Limestone 90, UVa-Wise 72 | Box score |
| 01/26/22 | Salisbury,NC (Goodman Gym) | Catawba 88, Limestone 81 | Box score |
| 01/24/22 | Gaffney, SC | Queens (NC) 80, Limestone 71 | Box score |
| 01/22/22 | Gaffney, SC | Anderson (SC) 77, Limestone 74 | Box score |
| 01/19/22 | Gaffney, SC | Newberry 77, Limestone 63 | Box score |
| 01/12/22 | Harrogate, TN | Lincoln Memorial 107, Limestone 72 | Box score |
| 12/20/21 | Gaffney, SC | Limestone 73, Converse 64 | Box score |
| 12/18/21 | Gaffney, SC | Limestone 73, Carson-Newman 71 | Box score |
| 12/15/21 | Hartsville, SC | Coker 65, Limestone 54 | Box score |
| 12/11/21 | Anderson, S.C. (Abney Center) | Anderson 81, Limestone 77 | Box score |
| 12/08/21 | Gaffney, SC | Catawba 101, Limestone 97 (2OT) | Box score |
| 12/01/21 | Wingate, N.C. | Wingate 82, Limestone 80 | Box score |
| 11/27/21 | Gaffney, SC | Limestone 70, Lenoir-Rhyne 54 | Box score |
| 11/23/21 | Greeneville, Tenn. | Tusculum 77, Limestone 68 | Box score |
| 11/20/21 | Newberry, SC | Limestone 62, Newberry 59 | Box score |
| 11/17/21 | Gaffney, SC | Limestone 82, UVa-Wise 72 | Box score |
| 11/13/21 | Milledgeville, GA | North Greenville 66, Limestone 60 | Box score |
| 11/12/21 | Milledgeville, GA | Limestone 80, Erskine 74 | Box score |