| Date | Location | Result | |
| 3/2/22 | Anderson, S.C. (Abney Center) | Anderson (S.C.) 67, Limestone 50 | Box score |
| 2/26/22 | Gaffney, S.C. (Timken Center) | Limestone 87, Lincoln Memorial 60 | Box score |
| 2/23/22 | Gaffney, S.C. (Timken Center) | Limestone 92, Mars Hill 51 | Box score |
| 2/21/22 | Hartsville, S.C. (DeLoach Center) | Limestone 58, Coker 52 | Box score |
| 2/19/22 | Jefferson City, Tenn. (Holt Fieldhouse) | Carson-Newman 100, Limestone 62 | Box score |
| 2/16/22 | Charlotte, N.C. (Curry Arena) | Limestone 76, Queens (N.C.) 56 | Box score |
| 2/14/22 | Harrogate, Tenn. (Turner Arena) | Limestone 56, Lincoln Memorial 51 | Box score |
| 2/12/22 | Gaffney, S.C. (Timken Center) | Tusculum 56, Limestone 49 | Box score |
| 2/9/22 | Gaffney, S.C. (Timken Center) | Wingate 69, Limestone 62 | Box score |
| 2/5/22 | Hickory, N.C. (Shuford Gym) | Limestone 81, Lenoir-Rhyne 66 | Box score |
| 2/2/22 | Gaffney, S.C. (Timken Center) | Limestone 67, Coker 51 | Box score |
| 1/31/22 | Mars Hill, N.C. (Stanford Arena) | Limestone 88, Mars Hill 56 | Box score |
| 1/29/22 | Wise, Va. (Prior Center) | UVA Wise 71, Limestone 55 | Box score |
| 1/26/22 | Salisbury, N.C. (Goodman Gymnaisum) | Catawba 73, Limestone 50 | Box score |
| 1/24/22 | Gaffney, S.C. (Timken Center) | Limestone 98, Queens (N.C.) 79 | Box score |
| 1/22/22 | Gaffney, S.C. (Timken Center) | Anderson (S.C.) 81, Limestone 60 | Box score |
| 1/19/22 | Gaffney, S.C. (Timken Center) | Newberry 79, Limestone 71 | Box score |
| 12/18/21 | Gaffney, S.C. (Timken Center) | Limestone 88, Carson-Newman 76 | Box score |
| 12/11/21 | Anderson, S.C. (Abney Center) | Anderson (S.C.) 71, Limestone 62 | Box score |
| 12/8/21 | Gaffney, S.C. (Timken Center) | Catawba 74, Limestone 62 | Box score |
| 12/4/21 | Gaffney, S.C. (Timken Center) | Limestone 73, Georgia College 44 | Box score |
| 12/1/21 | Wingate, N.C. (Cuddy Arena) | Wingate 94, Limestone 50 | Box score |
| 11/27/21 | Gaffney, S.C. (Timken Center) | Limestone 72, Lenoir-Rhyne 70 | Box score |
| 11/23/21 | Greeneville, Tenn. (Pioneer Arena) | Limestone 80, Tusculum 61 | Box score |
| 11/20/21 | Newberry, S.C. (Eleazer Arena) | Limestone 57, Newberry 43 | Box score |
| 11/17/21 | Gaffney, S.C. (Timken Center) | Limestone 75, UVA Wise 68 | Box score |
| 11/13/21 | Harrogate, Tenn. (Turner Arena) | Limestone 96, Converse 56 | Box score |
| 11/12/21 | Harrogate, Tenn. (Turner Arena) | Limestone 61, King (Tenn.) 60 | Box score |